Not really, but I don't use it that much, except maybe with tmux or less.

Yes. With the keyboard in 20-30 angle it forces me not to have my wrists flat on the table. Same with the mouse. The goldtouch mice used to be 45 degrees (and too light-weight for my taste), the newer models seem to be 30 degrees. When I work on the laptop for a week, e.g. while traveling, I need more breaks to rest my hands.