[1] http://robertwhitaker.org/robertwhitaker.org/Anatomy%20of%20...
In spite of everything, science is making a little bit of progress in understanding why people have various mental conditions. For the most part, patients are 'exhausted', because of poor metabolism, malnourishment, etc. Inflammation is a huge factor, as is cortisol deficiency.
I've posted some links before - see my comment history.