Tissue Nanotransfection

5 points by justintocci 8 years ago | 16 comments

Anyone have any real information on this?

I can see the news items all over but no real information on how it works, what the mechanism is, where the papers have been published, etc https://www.bing.com/search?q=Ohio+State+device+heals+organs...

sp332 8 years ago | |

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pimmdphd 8 years ago |

Knowing a little inside info about this development I must add a big word of caution on this science. It may be possible to add this type of coding in an optical format, in short the code may be able to be added say to a video and when someone watches the video the optical tissues in their eyes and retina may begin to transfer into whatever form of tissue is coded. This may indeed be able to effect brain tissue by this route of administration and that is terrifying!

Logicwax 8 years ago | |

Doesn't this require a physical package of some sort of bio material to be delivered to the cell, with electricity being used to open the cell membranes and push it through via ions? If I'm understanding that correctly, then how do you make the leap to optical-only transfer? It's almost as if you're claiming that an optical signal could somehow cause a buffer-overflow exploit in the cone/rod cells of a human eye, and then root the cell's "kernel" and start making run-time patches. And that sounds like a completely different scientific breakthrough than what this TNT stuff sounds like. could you elaborate any further?

Pardisheny 8 years ago | | |

Does sound interesting tho, just extrapolating but light/photons do contain energy and hence may just be able to initiate such an action. May depend on the type of display being used .

joonisboss 8 years ago |

So I was curious about this and read the supplemental pdf, thank you justintocci. The technology hinges on Nanochannel Electroporation as the storage and delivery vehicle for the DNA. Found the following paper (scrapped the url from Wiley) that goes into detail. The potential here is insane!

Joined Hacker News just to share it. :)

http://onlinelibrary.wiley.com/store/10.1002/advs.201500111/...

162256 8 years ago |

here are the supplemental data that have been released as "Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue" http://www.nature.com/nnano/journal/vaop/ncurrent/extref/nna...

cakra 8 years ago |

It looks like it is being advanced as a proprietary technology and they don't want to publish on the mechanism until it is commercialized. However there is a patent http://www.google.com.pg/patents/WO2010012077A1?cl=en

162256 8 years ago | |

I don't believe that patent is the relevant one.

grayzilla 8 years ago |

David Langford had a really great FAQ about this technology over on the comp.basilisk FAQ newsgroup:

http://ansible.uk/writing/c-b-faq.html

justintocci 8 years ago |

https://www.theengineer.co.uk/tnt-tissue-regeneration/

this gives better info of how it works but still no paper

162256 8 years ago | |

see supplemental data - https://images.nature.com/full/nature-assets/nnano/journal/v...

justintocci 8 years ago |

Ok, paper supposedly published here but searching finds no articles http://www.nature.com/nnano/index.html

CatMtKing 8 years ago | |

I think it's this one https://www.nature.com/nnano/journal/vaop/ncurrent/full/nnan...

prefect42 8 years ago | | |

...which has reference #14 has Sen listed as the author of another article (can't find direct link), here's #14 though: Sen, C. K. & Ghatak, S. miRNA control of tissue repair and regeneration. Am. J. Pathol. 185, 2629–2640 (2015).

162256 8 years ago |

they used "projection lithography, contact photolithography, and deep reactive ion etching –DRIE- to fabricate silicon-based TNT devices.

not clear what's proprietary.