Is Culture currently profitable? If not, how do you plan to be? When biotech companies fail, a lot of institutional knowledge tend to be lost so it is a great tragedy when one does.

The Y2K overshadowed the bubble for biotech companies, but similarly a lot of companies were hyped up but in the end achieved nothing. Not on the Theranos Level of failure but basically flops. A lot of basic research lead to dead ends, so funding and finances are pretty important.