I'm interested in how to organize teams and ways-of-work that work on projects that have a certain aspect of uncertainty, where they might not work, or require great investment (time or resources), inherently.

Like, how was the organization that Oppenheimer vouched for when he led the Manhattan Project, or how did Alan Turing lead the work at Bletchley Park?

Something that kind of scratched that question in my mind was the Veritasium [1] on the invention of the Blue LED (fascinating btw). But that endeavor was largely pursued by a single scientist. How would the work have been had a team of people worked on that problem?

Do large pharmaceuticals, which might be some of the companies that already have some practice in that, publish some books, even if just historical accounts?

1: https://www.youtube.com/watch?v=AF8d72mA41M