Lactate helps cancer cells resist chemotherapy(nature.com) |
Lactate helps cancer cells resist chemotherapy(nature.com) |
Just because lactate is produced from anaerobic exercise and this study found that lactate was used by the cancer cells, doesn't automatically follow that the cancer cells can use the lacate produced from exercise.
“ Lactate helps cancer cells resist chemotherapy The molecule lactate is a waste product of the metabolism of sugar without oxygen — a metabolic pathway preferentially used by cancer cells to generate their energy. Metabolomics analysis reveals that lactate in tumour cells promotes resistance to chemotherapy, and sheds light on the molecular mechanism that underlies this unexpected role of lactate in cancer”
And relevant to this conversation: we knew that a breakdown in these stages of cellular metabolism could result in tumors.
When the intensity of an exercise is low enough that you could sustain it for much more than a few minutes continuously, there should be no increased amount of lactate in the body.
How did you leap from (anaerobic) exercise to just exercise?
Just got back from a 3 mile walk and had my first chemotherapy yesterday. A little panic set in. Sounds like walking is still good. Thanks
Here's the thing with cancer (1) sometimes it actually does lack oxygen, because it grows faster than blood vessels, so may prefer lactate creation, known as "fermentation" (yes, like beer which ferments sugar to alcohol, but humans ferment sugar into lactate). So the whole body may be bedridden, not exercising, but a little part of it is not getting oxygen. (2) EVEN IF there is oxygen available to the cancer cell, they have been shown to, EVEN THOUGH there is oxygen there, they still proceed through fermentation and produce lactate. And it's not well known WHY cancer cells do this. This paper suggests that it's a chemo resistance mechanism. Other thoughts have been that it simply pushes through more physical carbon atoms which help make more cancer faster.... this concept of "why does the cancer ferment even though oxygen is readily available" is known as "The Warburg Hypothesis"
Because with oxygen 30x more ATP is produced. Why would cancer seek the vastly more inefficient energy production pathway, the insinct is that cancer would be hyperefficient at being canerous.
Dunning-Kruger energy here...
good luck to you fellow hacker.
Consider this #1. Your response is ghoulish.