I have a .me address and I've been totally happy with it. My domain is my initials (same as my HN username - nlh) and I love that my email is just nlh @ nlh . me -- it's actually shorter and better than any .com I could reasonably come up with or purchase.
There is confusion maybe 10% of the time - it's fine. Most of the confused people think I mean "me.com", but it hasn't been a real issue.
Honestly the more confusing thing for most people is that my initials are "nlh" and they are used to the National Hockey League (nhl) and that often ends up getting confused.
But again, all of these are minor. I love my .me domain and email address and am very happy to keep it for life.
(PS / side story: The .com I wanted for many years was "noah.com" because that was my tongue-in-cheek nickname among friends since I was an early internet adopter tech nerd. The domain was owned by a guy who had a 1990s-style single page homepage with no content other than a single link to a photo album -- that lived in stasis for years - easily throgh the mid/late 2010s. I would ping him every few years and ask if he was ready to sell it yet and he always demurred. Then recently I checked and it appears to have been sold to a fintech company. I guess they made him an offer he couldn't refuse!)