Psychotic disorders with cognitive impairment have brain metabolic dysregulation

2 points by arijo 1 year ago | 3 comments

"Conclusions: Our results demonstrate that psychotic disorders with greater cognitive impairment have greater brain metabolic dysregulation, with more reductive stress and decrease in energy metabolic rate markers. This provides new evidence for the potential of emerging metabolic therapies to treat cognitive deficits in psychotic disorders."

What this means is that metabolic interventions like ketogenic diet that improve brain metabolic function may be helpful in cognition for patients with psychotic illness. Or, in lay terms, "with better fuel for the brain, people with the most serious mental illnesses may be able to think better."

https://academic.oup.com/schizophreniabulletin/advance-article-abstract/doi/10.1093/schbul/sbaf003/7984396?redirectedFrom=fulltext&login=false

PaulHoule 1 year ago |

It's a classic rookie mistake on HN to submit a link as part of a discussion. Trouble is, people can't click on the link.

If you want people to have a discussion about a link submit the link, if you want to kick off the discussion with some commentary than feel free to post a comment.

Please delete this post and re-submit!

(Personally as a schizotype I think this is a super-interesting topic and it's also one that has been circulating for some time!)

arijo 1 year ago | |

I've already tried Paul.

Check my previous submission.

PaulHoule 1 year ago | | |

I upvoted.

In general HN doesn't like you editing titles other than simplifications to get them under the 80 char limit.

In your case without looking at the details I can believe there is a line connecting keto to what they're talking about "Brain Reductive Stress and Impaired Energy Metabolism" but I don't see it in detail.

I see interesting stuff for this PubMed search

https://pubmed.ncbi.nlm.nih.gov/?term=psychosis+ketogenic+di...

where the title matches your thesis. Writing a blog post that references a few articles and explains the connection and linking that would also be a good idea.