It's come up a few times on HN. [1] I've made reference to it in a cell phone thread half joking, knowing only some would get the reference. [2] I don't know if our civilization will get to that point. Only time will tell. If we are enslaved then I hope it's at least long after I and those related to me are long gone.

[1] - https://hn.algolia.com/?q=butlerian+jihad

[2] - https://news.ycombinator.com/item?id=43140431