The glass of the window does not have a frame. You want the glass to go into a rubber seal to really prevent air from getting in and whistling at high speeds. If there's a frame around it, then no problem, the seals move with the glass when you open the door. But if you don't have a frame then opening the door without retracting the glass will cause it to pull at the rubber seals. At best it'll wear the rubber faster, but eventually it'll pull the rubber seal out.

This is very common on cars where the windows don't have a frame. Before I had a Tesla I had a convertible Mustang. Because it was a soft top it didn't have the same kinds of seals. Instead it used lateral pressure to hold the window against some rubber. At freeway speeds the window would flex and let air in. Eventually the soft top started blocking the passenger side window from meeting the rubber, and there was always a 1/4" gap unless I rolled the window down a bit and then back up.