Ozempic and Wegovy linked to surprising drop in violent behavior(sciencedaily.com) |
Ozempic and Wegovy linked to surprising drop in violent behavior(sciencedaily.com) |
"But I being poor, have only my dreams. I lay my dreams upon your feet. Tread lightly, for you tread on my dreams."
I'm fairly sure that part of the reason they reduce neuroinflammation is because of pulmonary GLP-1 mechanisms. (Lung and brain are quite intimately connected, as is inflammation to the other two. As well as the gut. And… metabolism.)
Neuroinflammation is very behavior-modifying.
(Neuroinflammation kind of makes sense as an untamperable side-channel of information for neuronal processes – out of band; Protective. Can't think yourself to death.)
There's tons of papers to read. You wouldn't believe how much accurate and correct and actionable and predictive scientific information exists that nobody reads.
Read primary sources. Anyone can read. Don't let anyone tell you that you can't read. Least of all yourself.
These drugs seem to change something fundamental that reduces problematic behavior.
[1] https://www.youtube.com/watch?v=SSEjPuR11_k
[2] Diekhof EK, Nerenberg L, Falkai P, Dechent P, Baudewig J, Gruber O. Impulsive personality and the ability to resist immediate reward: an fMRI study examining interindividual differences in the neural mechanisms underlying self-control. Hum Brain Mapp. 2012 Dec;33(12):2768-84. doi: https://doi.org/10.1002/hbm.21398 Epub 2011 Sep 21. PMID: 21938756; PMCID: PMC6870517.
I wonder if you can do a simple experiment between glp and non glp users where you try and measure various biological response to giving someone say $20?
Going further I wonder if it affects other responses like pain response. How long might you keep your hand on a plate warming up? I seem to remember that sort of experimental setup in my undergrad days of signing up for every psychology department experiment under the sun for beer money.
In other words there's a concern of creating metaphorical "zombies" who lack a "force of will"
If I were a prison guard or warden I would be happy to encourage prisoners to use any compound that may improve their impulse control which is likely one of the root causes of their incarceration in the first place.
Research on prisoners is subject to stricter standards, though. From the HHS website:
> Research involving prisoners is permissible only if the research involves one or more of four permissible categories, or if the research meets the criteria described in an HHS Secretarial waiver that applies to certain epidemiological research [...]
> (i) the study of the possible causes, effects, and processes of incarceration, and of criminal behavior, and
> (ii) the study of prisons as institutional structures or of prisoners as incarcerated persons. [...]
> (iii) research on conditions particularly affecting prisoners as a class; [...]
> (iv) research on practices, either innovative or accepted, which have the intent and reasonable probability of improving the health or well-being of the subject. [...]
https://www.hhs.gov/ohrp/regulations-and-policy/guidance/faq...
The aggregate potential benefit is so high and the risk and cost reasonably low. Certainly, no one should ever be forced to take it, or be experimented on without their explicit, informed consent (and "experimented on" in this context is "taking the GLP-1 already and we're just tracking the outcomes at scale").