Unlikely for a number of reasons, and actually a large commercial constellation could help with scientific discovery.

Satellite trajectories are predictable from published ephemerides. It’s trivial for telescope operators to exclude the small fraction of pixels in a frame occupied by a satellite. They already do this.

Satellite operators are also careful not to transmit towards radio quiet zones https://en.wikipedia.org/wiki/Radio_quiet_zone

Furthermore, the same technology that makes it economical to put millions of satellites into LEO (e.g. Starship) also makes it cheaper to build larger telescopes in space where they’re unaffected by the earth’s atmosphere (and satellites in LEO).