To add some context, this is a relatively common form of gastritis impacting depending on location 3-5% of the population called Autoimmune Gastritis. Now his biohacking might be related it might not, the issue with the guy is that he does too many interventions at the same time so it’s hard to really tell what’s going on. He also has a core belief of equating looking younger with his interventions working, to his defence he also runs more rigorous analysis on his body. Overall he isn’t the most interesting bio hacker out there, but he is the loudest.

His idea would be cool if not for the lindy effect: each one of his "tests" has a somewhat low probability of extending his life by a few months / years.

However each of his tests, as they are new, also has a smaller probability of having ruin effect: killing him or leaving him disabled in the process. Multiplying the treatments increases significantly the downside risks (1 failure is enough) while the positive will not compound (you will need many of them to work to see a significant effect).

It seems like a high-prevalence low-impact disease. Considering how much he self-scans it’s no surprise he found one of these. The cancers that he could get as a result are not particularly dangerous and lifespan is barely affected by it.

Seems interesting but not consequential.

This is heartbreaking to see (from the doc about this guy, he seemed to genuinely believe this was a good idea). A good warning about the limits of control humans have over things (and why brute-forcing it can often lead to bad outcomes).

I wonder if the methods he used are any better than all sorts of incantations or ancient “cures”…a worthy goal that proved money can’t solve the ultimate disease…yet!

There is nothing more valuable than doing what you believe and love in the life. Especially when doing no harm, furthermore trying to solve a great problem with great benefits for society.

Is incredible but understandable, many don´t get it.

[dupe] Discussion: https://news.ycombinator.com/item?id=48804049

I thought the article was talking about his blood transfusions to explain any part of how he ended up with this disease but no, he just has it (for some reason) as a result of something that happened at some point.

Now this news is everywhere and people seem to be mocking him, but he is a good guy.

I completely support people who want to be guinea pigs for health science.

He's hubristic and selfish. None of his "research" is going to benefit anyone (himself included), making this essentially a huge waste of time and resources. Bryan will die just like all the rest of us, despite being very rich and self-obsessed. He could spend his enormous wealth on supporting real research and proper studies on real diseases that hurt lots of people. Instead he's acting like just another huckster promising a fountain of youth. He does this using bombastic terms and taboo methods (e.g. using his son as a blood boy), in a way that's calculated to direct enormous public attention towards himself. The science he advocates for is sketchy at best and the results of all his "experiments" will tell us nothing because we can't reproduce his methods (his program allegedly costs >$1M per year), nothing is blinded or controlled, and N=1. He's a bad person who uses bad methods to glorify himself and now he probably gave himself an autoimmune disease. He deserves to be mocked.

Fwiw, people mocked him long before this news broke. People aren't hating on him as a result of his diagnosis, just found a new (and admittedly ironic) point to pick at.

> but he is a good guy

That definitely doesn't seem to be the case, especially if you look beyond his bio-hacking endeavors. His treatment of employees and ex-partners seems pretty horrible: https://www.nytimes.com/2025/03/21/technology/bryan-johnson-...

He’s unfathomably rich and unfathomably stupid; doing insane shit to his body and actively recommending others do the same and that’s why he’s being mocked.

“Good guy” or not, he’s paying the price for playing with fire.

I mean, you never know for sure. It's all just PR and messaging. Especially from a tech CEO with money. The thing that I struggle to reconcile is how much he's been involving his teenage son in this experimentation. That's a pretty gigantic red flag for me, I guess.

Being good and wealthy are mutually exclusive.