I invested heavily in ICOS when they launched, they had Bill Gates money and were looking for ways to extend lifespans and solve inflammation.

And all we got was another boner pill.

Fascinating! I have non-hearing damage induced Tinnitus and Bipolar Disorder and have been interesting in my PDE genetics for sometime as a link to my issues. It seems I have a natural inhibition of many PDE genes (PDE4B specifically, but I have some less studied changes in my PDE5A genetics which suggests an inhibition there as well).

Sildenafil has been know to make BP people relapse in one case...

https://academic.oup.com/ijnp/article/7/4/525/707950?login=f...

And also investigated with some mood issues...

https://link.springer.com/article/10.1007/s00213-023-06361-3

Zinc and Magnesium are cofactors for all the PDE genes and those have helped me, specifically the zinc.

I have a feeling that low GTP is causing issues in ED since Cyclic GMP is made from GTP.

Study link and/or source?

> Check your blood pressure regularly.

Also avoid things that increase blood pressure and do more thing that improve your cardiovascular system. No amount of drug will make up for decades of abuse

Very interesting. Since you've spent some time thinking about it, what's your hypothesis of the connection between high blood pressure and dementia? Any interesting links you could share?

Maybe high blood pressure causing more pressure in the blood vessels of the brain, leading to a lifetime or decades of cumulative damage?

I wonder if flomax (tamsulosin) figures into all this because lowered blood pressure can be a side effect.

>Beet juice, exercise, and eating nitrate-rich vegetables are some non-pharmaceutical ways to have a similar effect.

Add deep breathing to that list too, believe it or not!

I thought nitrates were dangerous with regard to cancer. (?)

Just an FYI, these drugs don't actually cause erections or sexual excitement. They simply make erections easier.

Now, if someon is mildly excited by other bodybuilders but usually not enough to make it known, yes Cialis could cause 'movement' as George Costanza put it.

But if you're not into what's in front of you, Cialis isn't going to change anything.

>weightlifters taking viagra to increase their blood flow when working out at the gym

The weightlifting community moved off of Viagra years ago due to Cialis having a much longer half life.

It’s the hardcore version of beet juice powder, which athletes often take to…increase blood flow. As a user, I can’t say whether it helps with Viagra’s advertised purpose.

If that's the weirdest thing you've heard of weightlifters doing, you are lucky.

L-Citrulline supplements are also commonly used.

https://www.webmd.com/vitamins-supplements/l-citrulline#uses

Cialis is most common and it is typically low dose, like 5mg/day. Can still provoke unwanted “movement” in a gym environment however.

Monkey paw wish - you will live longer, but you will be constantly erect.

Can't rule out exercise.

I used to hear that sexually active couples lived longer, so there's that.

Serious lifelong runner here, and it’s news to me. OTOH, it may be an influencer bro-science thing that I’ve successfully ignored.

OTOOH, I take beet juice powder, which is to increase blood flow pre-run, so I would not be surprised if folks “leveled up” to a pharmaceutical.

I would imagine the sex itself isn’t super relevant in terms of exercise. But people who seek out medical treatment (or enhancement) likely take better care of themselves in general.

But I would be surprised if there were not a measurable increase in health markers for men who take Cialis. Pretty much any drug that reduces blood pressure is going to have a positive effect on longevity for the average male population (but not the sub-population who have low blood pressure).