Why can't I spend $99 and find out if I have a prominent heart disease marker, that killed both my father and grandfather by 55? Because the healthcare market is regulated by the government for the benefit of various cartels. They want me to spend thousands of dollars and be forced to go through layers of doctors to get the same results instead.
The datasets used by 23andMe to interpret your genetic variants are the same datasets that you can get access to for free! If you know how to program, then you can use public datasets from the NCBI (http://www.ncbi.nlm.nih.gov/) or SolveBio (my startup, http://solve.bio) to compare your raw data to the clinical reference information you're interested in.
1) Illumina/Solexa's breakthrough was to convert sequencing into a problem limited by computing resources (reassembling the jigsaw), so they were able to leverage improvements in semiconductor processing.
2) This quote grabbed me:
"But Flatley is confident that Illumina’s footprint, which includes not just machines but also the software to handle genomic data, will make the company hard to unseat."
A call to arms for the Free Software movement?
Illumina's chemistry was better than the others, and they marketed their advantages better. The Illumina machine produced longer reads than SOLiD (Life Technologies), and produced more reads than 454 (Roche). They produced reliable instruments that were relatively easier to use than the others also, which made them favorites for core facilities.
No chance, these algorithms are too dependent on very expensive hardware that sole coders can't afford.