I am wondering how much immune "budget" do humans have for vaccines? This topic is left unadressed and is extremely worrying, being an existential risk. Basically, the body has a limited amount of unspecialized naive T cells in its lifetime, mostly located/modulated in the thymus gland, which involute quickly with age.

I suppose that 1) vaccines increase the rate of specialisation of naive T cells to mature t cells (hence the number of naive t cells diminish supraphysically)and I also believe that

2) those specific mature T cells, generating covid spike protein specific antibodies, have lost some or total ability to fight non-covid diseases as a cost of specialization. 1) would increase thymus involution rate and therefore age speed of immunosupression.

2) would reduce generic immune ability (learning other pathogens)

3) I believe the increased immune profile after a vaccine induce a long lasting (at least 6 month) increase of accelerated aging process in humans, via increased inflammation and therefore apoptosis, DNA mutations and oxidative stress, although in a mild form and hence in the medium term asymptomatic.

Above all the premises I enumerated, the 2) is the one I would draw the most attention to, which can be reformulated as: do the repetitive administrations of a vaccine (here the 3 mRNA doses), reduce the effectiveness of the immune system for future non-COVID diseases, and even more importantly, does those doses reduce the immune learnability budget and therefore do those vaccines reduce the effectiveness of future vaccines against the next non-COVID pandemic? There has to be a limit to immune memory, the question is, after how many vaccines do the effect become non-negligible on aging?

study backing chronic inflammation and therefore accelerated aging: > vaccine-induced hypermetabolic lymph nodes https://pubmed.ncbi.nlm.nih.gov/34857663/

study backing the depletion of lymphocite T helper cell production: Study Shows Immune Cells Against Covid-19 Stay High in Number Six Months After Vaccination https://www.hopkinsmedicine.org/news/newsroom/news-releases/....

Moreover, I have an issue understanding why would vaccine not massively lose effectiveness after the age of 70 since at 70 the thymus has ~completely involuted (although maybe the stem cells in the bone marrow suffice?).

1.	C.elegans is NOT the life form with the smallest brain(en.wikipedia.org) 1 points by SemanticStrengh 3 years ago \| 0 comments
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user:	SemanticStrengh
created:	April 23, 2022
karma:	999