15:[[40892183,{"by":"zdw","descendants":104,"id":40892183,"kids":[40894678,40894597,40894705,40894735,40896073,40895114,40894643,40895446,40894625,40894734,40894739,40895804,40894992,40895270,40894815,40894376,40895363,40894895,40894903,40894838],"score":83,"time":1720290418,"title":"Why haven't biologists cured cancer?","type":"story","url":"https://www.writingruxandrabio.com/p/why-havent-biologists-cured-cancer"}],[37576192,{"by":"mriguy","descendants":9,"id":37576192,"kids":[37579946,37588517,37576680,37576252,37581371,37594909],"score":8,"text":"Medical device cybersecurity has become a significant area of focus for the FDA. Starting Oct 1, 2023, the FDA will issue a 'Refuse To Accept' letters to 510K submissions that do not comply with the amended Section 524B of the FD&C Act.

Most of the online resources related to medical device cybersecurity are from companies selling solutions.

Are there examples of high-quality independent blogs, resources for medical device professionals to refer to educate themselves?","time":1695155980,"title":"Ask HN: What are some good resources to understand medical device cybersecurity?","type":"story"}],[37589319,{"by":"rrmdp","descendants":7,"id":37589319,"kids":[37589391,37593735,37609802,37589902,37594864,37589383,37598439],"score":5,"text":"I've been using Thunderbird for years but wonder if there is a better option.","time":1695239994,"title":"Ask HN: What's the best email client for Windows?","type":"story"}],[37592540,{"by":"Supply5411","descendants":26,"id":37592540,"kids":[37592824,37594117,37593506,37592909,37604885,37593220,37594840,37593313],"score":8,"text":"Some engine must hooking into the LLM to answer questions like these. Are there any details about this process?

https://chat.openai.com/share/696def43-be52-4574-ad18-4f8ecf8557b0

EDIT: An even longer, more convincing test https://chat.openai.com/share/417169ed-8256-46cb-a3ed-81ab06a1d70b","time":1695262696,"title":"Tell HN: ChatGPT Can Decode Base64","type":"story"}],[37594461,{"by":"jdjdjdjdjdjd","descendants":163,"id":37594461,"kids":[37594754,37594602,37594692,37595773,37594724,37595129,37594963,37600645,37595002,37599205,37594695,37594827,37595038,37595029,37599303,37594838,37594593,37615274,37599662,37595158,37595093,37595221,37595194,37595033,37607282,37598121,37594771,37597836,37595123,37594753,37594849,37598668,37596161,37594866,37595041,37604152,37595618,37595010,37595027,37605800,37600319,37597865,37594819,37594727,37671289,37597151,37594905],"score":69,"text":"I studied humanities in university. But I've been programming since I was a kid, so it was a natural career choice. I regret not doing CS. I work for a public sector org and have been promoted to a senior developer.

But I still don't think this is enough for me to make the move to FAANG or other tech companies unless I stay here for a long time to rack up experience (I only have 2 years SWE experience at this point). Also, as the org I work for is not a tech company, I'm not sure how seriously recruiters will take my time here.

I've studied data structures and algorithms, and I think I am a decent programmer. I could probably progress quite quickly through CS50 or some other online course. I just don't know if it's beneficial.

This topic online is full of misinformation and people just trying to sell you a course. So this seemed a good place to ask.

I'm UK-based by the way.

Thanks.","time":1695282503,"title":"Ask HN: I'm a SWE without a CS degree. Will online certs help me get into FAANG?","type":"story"}],[37360186,{"by":"tobr","descendants":7,"id":37360186,"kids":[37363838,37364935,37361723,37362277,37361919,37363479],"score":74,"time":1693650482,"title":"Recursive Racks [video]","type":"story","url":"https://www.youtube.com/watch?v=ckrrQTkTqIo"}],[36370409,{"by":"Tomte","descendants":113,"id":36370409,"kids":[36374816,36370807,36371940,36373157,36370914,36371294,36371770,36372740,36375632,36376486,36372596,36376574,36378388,36371818,36374585,36373325,36371225,36371275,36372454,36371526,36372696,36371184,36372674,36372719],"score":50,"time":1687011777,"title":"KC archbishop clarifies wine validity norms","type":"story","url":"https://www.pillarcatholic.com/p/kc-archbishop-clarifies-wine-validity"}],[35857631,{"by":"bgun","descendants":86,"id":35857631,"kids":[35858118,35858154,35857934,35858086,35857676,35858149,35858068,35858227,35858519,35858339,35858271,35858157,35863018,35861061,35866422,35858288,35858013,35860637,35857890],"score":41,"text":"$16","time":1683514740,"title":"Ask HN: Why is the state of “smart home” devices still so dire?","type":"story"}],[34722432,{"by":"drcpp","descendants":44,"id":34722432,"kids":[34726227,34724633,34725641,34729903,34731581,34726583,34726797,34726618,34723086,34724722,34723991,34724773,34733476,34725676,34734914,34724162,34732917,34723924],"score":99,"text":"Hi HN,

I have been working on a set of PDF tools that does all the processing directly in the web browser. From time to time I needed to do some simple PDF manipulations like merging PDF files. Sometimes the files contain my personal data and I was not comfortable using other online services where the file usually is uploaded to a remote server.

Behind the scenes there is a small library written in C++ doing the changes to the PDF files. I am using the Emscripten compiler to compile it to WebAssembly that is running in the browser. It was a very good learning for me and it was easier than I thought to get something working, credits to the Emscripten project. The tool is also a PWA and can be used offline (once loaded).

I am looking for any kind of feedback, comments or ideas for new tools that I could add.","time":1675942348,"title":"Show HN: Privacy friendly suite of PDF tools","type":"story","url":"https://pdfux.com/"}]]

user:	thesimpleone
created:	December 6, 2022
karma:	2